Submacular combination treatment for management of acute, massive submacular hemorrhage in age-related macular degeneration.
Ophthalmic Surg Lasers Imaging
; 40(3): 308-15, 2009.
Article
em En
| MEDLINE
| ID: mdl-19485299
ABSTRACT
A surgical technique is described combining submacular anti-vascular endothelial growth factor (anti-VEGF) and recombinant tissue plasminogen activator (r-TPA) with pneumatic displacement of massive submacular hemorrhage in age-related macular degeneration. An 84-year-old man with a large, acute submacular hemorrhage secondary to age-related macular degeneration underwent combination vitrectomy, submacular anti-VEGF and r-TPA injection with pneumatic displacement of the hemorrhage. At the last follow-up visit, 7 months after surgery, visual acuity was 20/80 with a small fibrovascular pigment epithelial detachment and atrophic retinal pigment epithelial changes. A 77-year-old woman with known age-related macular degeneration underwent a similar surgical procedure for a similar acute, large submacular hemorrhage related to age-related macular degeneration. Nine months after surgery, the visual acuity was 20/70(-1). Combination submacular anti-VEGF therapy delivered at the time of pars plana vitrectomy and submacular tissue plasminogen activator assisted hemorrhage displacement may be a viable treatment strategy for the management massive submacular hemorrhage.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vitrectomia
/
Hemorragia Retiniana
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Ativador de Plasminogênio Tecidual
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Inibidores da Angiogênese
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Fibrinolíticos
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Degeneração Macular
Tipo de estudo:
Etiology_studies
Limite:
Aged
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Aged80
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Female
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Humans
/
Male
Idioma:
En
Revista:
Ophthalmic Surg Lasers Imaging
Assunto da revista:
OFTALMOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos