Vitamin A supplementation reduces measles morbidity in young African children: a randomized, placebo-controlled, double-blind trial.
Am J Clin Nutr
; 54(5): 890-5, 1991 Nov.
Article
em En
| MEDLINE
| ID: mdl-1951162
ABSTRACT
The effects of vitamin A supplementation on measles morbidity are unclear. Sixty hospitalized children aged 4-24 mo with complicated measles received a World Health Organization--(WHO) recommended dose of vitamin A or placebo. The two groups were comparable in known covariants of measles severity weight-for-age percentiles, overcrowding, rash, total lymphocytes, and serum concentrations of zinc, albumin, prealbumin, retinol-binding protein, and vitamins A and E. Ninety percent of the patients had hyporetinemia. Integrated morbidity scores, determined by severity of condition (eg, diarrhoea, herpes, and respiratory-tract infection) were assigned on day 8 and 6 wk and 6 mo; these were reduced by 82%, 61%, and 85%, respectively, in the supplemented group, which was mainly due to reduced respiratory-tract infection. There was one death in the placebo group. At 6 wk weight gain was significant in the supplemented group. Despite the selected sample, attention to multiple covariates enhances the validity of the data obtained and supports the current WHO recommendations for vitamin A supplementation during measles.
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Base de dados:
MEDLINE
Assunto principal:
Vitamina A
/
Sarampo
Tipo de estudo:
Clinical_trials
Limite:
Humans
/
Infant
País/Região como assunto:
Africa
Idioma:
En
Revista:
Am J Clin Nutr
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
África do Sul