In vitro effect of a new cinnamic acid derivative against the epimastigote form of Trypanosoma cruzi.
Arzneimittelforschung
; 59(4): 207-11, 2009.
Article
em En
| MEDLINE
| ID: mdl-19517898
ABSTRACT
An intensive effort has been directed toward finding alternative drugs for treatment of Chagas' disease, caused by Trypanosoma cruzi (T. cruzi), and prophylaxis of blood in endemic areas. The preparation and in vitro evaluation as potential anti-protozoal agent of (2E)-N-(1,3-benzothiazol-2-yl)-3-(2,5-dimethoxyphenyl)-2-propenamide (CAD-1) is presented. The results show that 0.05 mM CAD-1 induced 58.1% of T. cruzi epimastigotes death; mainly by apoptosis. The diminution in the transmembrane mitochondrial electrical potential together with the increase in the intracellular generation/accumulation of reactive oxygen species, suggest the parasites mitochondria as the main target for CAD-1-induced death. The concentration of 0.05 mM CAD-1 is not low enough to consider it as a potent tripanocydal agent. However the novel mechanism that induces T. cruzi death, together with the novelty of its chemical structure, point out CAD-1 as a head group compound that could serve as a template to obtain new, more potent anti-Chagas disease agents.
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Base de dados:
MEDLINE
Assunto principal:
Tripanossomicidas
/
Trypanosoma cruzi
/
Cinamatos
/
Benzotiazóis
/
Amidas
Limite:
Animals
Idioma:
En
Revista:
Arzneimittelforschung
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Cuba