Diabetic retinopathy is not associated with carbonic anhydrase gene polymorphisms.
Mol Vis
; 15: 1179-84, 2009 Jun 13.
Article
em En
| MEDLINE
| ID: mdl-19536309
ABSTRACT
PURPOSE:
Carbonic anhydrase is elevated in the vitreous of patients with proliferative diabetic retinopathy (PDR). This study aimed to determine if common polymorphisms in the carbonic anhydrase (CA) gene influence susceptibility to diabetic retinopathy (DR).METHODS:
In this multicentered study, a total of 235 control subjects with no DR, 158 subjects with nonproliferative DR (NPDR), 132 with proliferative DR (PDR), and 93 with clinically significant macular edema (CSME) were recruited. Blinding DR was defined as severe NPDR, PDR or CSME. DR subjects were drawn from both type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) populations. Ten tag single nucleotide polymorphisms were selected to cover the majority of genetic diversity across the CA gene.RESULTS:
After adjustments were made for sex, disease duration, and HbA(1)c, no associations were found between any CA polymorphisms or haplotypes with any type of retinopathy in T1DM or T2DM.CONCLUSIONS:
Sequence variation in CA is not associated with the risk of developing retinopathy in T1DM or T2DM and increases the likelihood that elevated vitreous CA may be a consequence rather than cause of DR. Further genetic studies are required to have a better understanding of the pathogenesis of this debilitating diabetic complication.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Anidrases Carbônicas
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Polimorfismo de Nucleotídeo Único
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Retinopatia Diabética
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
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Humans
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Male
/
Middle aged
Idioma:
En
Revista:
Mol Vis
Assunto da revista:
BIOLOGIA MOLECULAR
/
OFTALMOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Austrália