Vascular risk factors and their association to serum androgen levels in a population-based cohort of 75-year-old men over 5 years: results of the VITA study.
World J Urol
; 28(2): 209-14, 2010 Apr.
Article
em En
| MEDLINE
| ID: mdl-19562348
ABSTRACT
PURPOSE:
In contrast to the high prevalence of late onset hypogonadism, little is known regarding correlates for low androgen levels in aging men.METHODS:
We investigated participants of the Vienna Transdanube Aging study and assessed the relationship between vascular risk factors and hormonal status over 5 years.RESULTS:
A total of 247 men with a mean age of 75.8 years were analyzed. Despite a tendency for lower testosterone levels in men with vascular risk factors and vascular diseases, none of these associations reached statistical significance. Men with low DHEA-S levels had a lower risk of hypercholesterinemia (-55.2%; P = 0.01) yet an increased prevalence of diabetes (+95.7%; P = 0.02) and coronary heart disease (+47.6%; P = 0.05). Testosterone and DHEA-S remained stable over 5 years of follow-up.CONCLUSION:
While reduced levels of total testosterone did not show an association to vascular disease, low DHEA-S was linked to hypercholesterinemia, diabetes, and coronary heart disease.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Testosterona
/
Envelhecimento
/
Sulfato de Desidroepiandrosterona
/
Aterosclerose
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Aged
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
World J Urol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Áustria