Plasma level of granulocyte-colony stimulating factor during granulocyte and monocyte adsorptive apheresis in patients with ulcerative colitis.
Hepatogastroenterology
; 56(90): 348-51, 2009.
Article
em En
| MEDLINE
| ID: mdl-19579596
ABSTRACT
BACKGROUND/AIMS:
Cytapheresis with extra-corporeal circulation for ulcerative colitis is effective but its mechanisms are still unclear. Granulocytecolony stimulating factor (G-CSF) strongly mobilizes bone marrow-derived cells and serves as antiinflammatory factor. We investigated plasma levels of G-CSF during granulocyte and monocyte adsorptive apheresis (GCAP).METHODOLOGY:
Nineteen cases of ulcerative colitis were measured plasma concentration of G-CSF during the first session of GCAP therapy.RESULTS:
G-CSF were significantly increased in the column inflow at 30 min compared with the baseline (Wilcoxon test, p < 0.01), and also increased through the column (Wilcoxon test, p < 0.01). The ratio of the increase in the column outflow at 60 min was 1.5-fold compared with the baseline. However, we could not show a significant relation between G-CSF level and clinical efficacy.CONCLUSIONS:
This is the first report concerning G-CSF during CAP. G-CSF is increased due to GCAP and appears to be a candidate which should be further investigated.
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Base de dados:
MEDLINE
Assunto principal:
Remoção de Componentes Sanguíneos
/
Colite Ulcerativa
/
Fator Estimulador de Colônias de Granulócitos
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Hepatogastroenterology
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Japão