Inflammation but not endothelial dysfunction is associated with the severity of coronary artery disease in dyslipidemic subjects.
Mediators Inflamm
; 2009: 469169, 2009.
Article
em En
| MEDLINE
| ID: mdl-19584917
ABSTRACT
INTRODUCTION:
Endothelial dysfunction and inflammation play a key role in the development of atherosclerosis. The present study evaluated endothelial function, inflammatory parameters, and carotid intima-media thickness (IMT) in dyslipidemic patients with or without coronary artery disease (CAD).METHODS:
Metabolic profile and inflammatory parameters were determined in dyslipidemic patients with (+CAD, n = 33) and without (-CAD, n = 69) symptomatic CAD. Endothelial function was evaluated by flow mediated dilatation (FMD) and plasma concentration of nitrites and nitrates. Carotid IMT was measured by ultrasound.RESULTS:
No significant differences were observed in anthropometric hemodynamic or metabolic parameters between the groups. After adjusting by age and medication usage, some inflammatory markers were significantly higher in +CAD; however no significant differences in FMD or plasma levels of nitrites were observed.CONCLUSIONS:
In subjects with dyslipidemia, the presence of CAD is associated with an elevation of certain inflammatory markers and carotid IMT but not with further endothelial dysfunction.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doença da Artéria Coronariana
/
Endotélio Vascular
/
Dislipidemias
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Mediators Inflamm
Assunto da revista:
BIOQUIMICA
/
PATOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Colômbia