Pyridinium ylide-assisted one-pot two-step tandem synthesis of polysubstituted cyclopropanes.
J Comb Chem
; 11(6): 1007-10, 2009.
Article
em En
| MEDLINE
| ID: mdl-19603746
ABSTRACT
A sequential one-pot two-step tandem reaction for efficient synthesis of polysubstituted cyclopropanes has been developed. The three-component reaction of alpha-halogenated methylene compounds, aromatic aldehydes, and acetonitrile derivatives produced first the intermediates pyridinium salts and electron-deficient olefins, followed by cyclopropanation of pyridinium ylide with electron-deficient olefins in situ to afford polysubstituted cyclopropanes. Target compounds were obtained in high yields and were diastereomerically pure after recrystallization.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Compostos de Piridínio
/
Técnicas de Química Combinatória
/
Ciclopropanos
Idioma:
En
Revista:
J Comb Chem
Assunto da revista:
QUIMICA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
China