Severe HIV-associated hypertriglyceridaemia treated with rosuvastatin plus omega-3 fatty acids.
Int J STD AIDS
; 20(8): 580-1, 2009 Aug.
Article
em En
| MEDLINE
| ID: mdl-19625595
ABSTRACT
Compared with healthy controls, HIV patients already have abnormal lipoprotein concentrations before the initiation of highly active antiretroviral therapy (HAART), which worsen with the therapy. HAART-associated dyslipidaemia features fundamental proatherogenic changes such as increased plasma triglycerides (TGs), increased total cholesterol and low-density lipoprotein cholesterol as well as decreased high-density lipoprotein cholesterol (HDL-C). The current guidelines for managing HIV-associated dyslipidaemia recommend diet and exercise counselling, alteration of HAART regimen or addition of lipid-lowering medications such as statins, fibrates and omega-3 (OM-3) fatty acids. Given that cardiovascular risk significantly increases with elevated lipid levels, selecting a drug to manage dyslipidaemia is particularly important. A case is described of an HIV patient who had severe hypertriglyceridaemia and bad metabolic parameters treated with rosuvastatin and OM-3 fatty acids. So we obtained a more marked reduction of TG levels than has never been described before in the literature, associated with a significant increase in HDL-C levels.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirimidinas
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Sulfonamidas
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Hipertrigliceridemia
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Ácidos Graxos Ômega-3
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Infecções por HIV
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Inibidores de Hidroximetilglutaril-CoA Redutases
/
Fluorbenzenos
Tipo de estudo:
Guideline
/
Risk_factors_studies
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Int J STD AIDS
Assunto da revista:
SINDROME DA IMUNODEFICIENCIA ADQUIRIDA (AIDS)
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Itália