[Efficacy of combined active-passive immunization in neonates born to hepatitis B surface antigen positive mothers: a study of 60 cases]. / Efficacité de la sérovaccination chez des nouveau-nés de mères antigènes HBs positif: à propos de 60 observations.
J Gynecol Obstet Biol Reprod (Paris)
; 38(6): 500-9, 2009 Oct.
Article
em Fr
| MEDLINE
| ID: mdl-19656641
ABSTRACT
OBJECTIVES:
To evaluate the efficacy of hepatitis B serovaccination in neonates born to HBsAg carrier mothers. MATERIALS ANDMETHODS:
This study was performed in neonates born to HBsAg carrier mothers. They received one dose of hepatitis B immunoglobulins (0.3 ml/kg) at birth and four doses of vaccine (0, 1, 2 and 12 months of age). A second dose of hepatitis B immunoglobulins was given at 1 month of age in neonates born to hepatitis B antigen-positive carrier mothers.RESULTS:
Sixty infants were included. Fifty-seven infants (95.0%) were not infected. The two infected infants were born to hepatitis Be antigen-positive carrier mothers. One infant was chronically infected by hepatitis B virus antenatal transmission and the second one developed an acute hepatitis by vertical perinatal transmission. One to 3 months after the third vaccinal dose, 16 infants (31.4%) were poor responders to vaccine.CONCLUSION:
The hepatitis B serovaccination is efficient with four vaccinal doses. In infants born to hepatitis Be antigen-positive carrier mothers the efficacy could be improved increasing the dose of hepatitis B immunoglobulins (0.6 ml/kg) at birth and adding a second dose (0.6 ml/kg) at 3 weeks of life. A careful serological follow-up could be also suggested.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vacinas contra Hepatite B
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Hepatite B
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Antígenos de Superfície da Hepatite B
Limite:
Female
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Humans
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Male
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Newborn
Idioma:
Fr
Revista:
J Gynecol Obstet Biol Reprod (Paris)
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
França