[Effects of quercetin on the expression of VEGF-C and VEGFR-3 in human cancer MGC-803 cells].
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
; 25(8): 678-80, 2009 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-19664387
ABSTRACT
AIM:
To investigate the mechanism of quercetin on the inhibition of the lymphatic metastasis in human gastric cancer cells MGC-803.METHODS:
Cells were divided into the control group and the quercetin (Que)-treated group. Immunohistochemistry and RT-PCR were used to detect the expression of vascular endothelial growth factor C (VEGF-C) and VEGFR-3 of human gastric cancer cells MGC-803 in response to Que.RESULTS:
Que significantly decreased the expression of VEGF-C and VEGFR-3 at 40 mumol/L compared with the control group after 48 h (P<0.01).CONCLUSION:
Que can down-regulate the expression of VEGF-C and VEGFR-3 in human gastric cancer cells MGC-803.
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Base de dados:
MEDLINE
Assunto principal:
Quercetina
/
Neoplasias Gástricas
/
Regulação para Baixo
/
Receptor 3 de Fatores de Crescimento do Endotélio Vascular
/
Fator C de Crescimento do Endotélio Vascular
Limite:
Humans
Idioma:
Zh
Revista:
Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
China