Structure and catalytic mechanism of the beta-carbonic anhydrases.
Biochim Biophys Acta
; 1804(2): 362-73, 2010 Feb.
Article
em En
| MEDLINE
| ID: mdl-19679201
ABSTRACT
The beta-carbonic anhydrases (beta-CAs) are a diverse but structurally related group of zinc-metalloenzymes found in eubacteria, plant chloroplasts, red and green algae, and in the Archaea. The enzyme catalyzes the rapid interconversion of CO(2) and H(2)O to HCO(3)(-) and H(+), and is believed to be associated with metabolic enzymes that consume or produce CO(2) or HCO(3)(-). For many organisms, beta-CA is essential for growth at atmospheric concentrations of CO(2). Of the five evolutionarily distinct classes of carbonic anhydrase, beta-CA is the only one known to exhibit allosterism. Here we review the structure and catalytic mechanism of beta-CA, including the structural basis for allosteric regulation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Anidrases Carbônicas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos