Apoptosis signal-regulating kinase 1 regulates the expression of caspase-11.
FEBS Lett
; 583(18): 3016-20, 2009 Sep 17.
Article
em En
| MEDLINE
| ID: mdl-19695249
ABSTRACT
Caspase-11 is an inducible caspase involved in the regulation of cell death and inflammation. In the present study, we examined whether apoptosis signal-regulating kinase 1 (Ask1)-mediated signaling pathway is involved in the expression of caspase-11 induced by lipopolysaccharide (LPS). We found that the induction of caspase-11 was suppressed by the inhibitors of NADPH oxidase (Nox) or knockdown of Nox4 that acts downstream of toll-like receptor 4 and generates Ask1-activating reactive oxygen species. Overexpression of dominant negative tumor necrosis factor receptor associate factor 6 also suppressed the induction of caspase-11. Importantly, knockdown or dominant negative form of Ask1 suppressed the induction of caspase-11 following LPS stimulation. Taken together, our results show that Ask1 regulates the expression of caspase-11 following LPS stimulation.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Regulação da Expressão Gênica
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Caspases
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MAP Quinase Quinase Quinase 5
Limite:
Animals
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
2009
Tipo de documento:
Article