Tickets to ride: selecting cargo for clathrin-regulated internalization.
Nat Rev Mol Cell Biol
; 10(9): 583-96, 2009 Sep.
Article
em En
| MEDLINE
| ID: mdl-19696796
ABSTRACT
Clathrin-mediated endocytosis oversees the constitutive packaging of selected membrane cargoes into transport vesicles that fuse with early endosomes. The process is responsive to activation of signalling receptors and ion channels, promptly clearing post-translationally tagged forms of cargo off the plasma membrane. To accommodate the diverse array of transmembrane proteins that are variably gathered into forming vesicles, a dedicated sorting machinery cooperates to ensure that non-competitive uptake from the cell surface occurs within minutes. Recent structural and functional data reveal remarkable plasticity in how disparate sorting signals are recognized by cargo-selective clathrin adaptors, such as AP-2. Cargo loading also seems to govern whether coats ultimately bud or dismantle abortively at the cell surface.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Clatrina
/
Vesículas Revestidas por Clatrina
/
Complexo 2 de Proteínas Adaptadoras
/
Endocitose
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Nat Rev Mol Cell Biol
Assunto da revista:
BIOLOGIA MOLECULAR
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos