Tcf3 and Tcf4 are essential for long-term homeostasis of skin epithelia.
Nat Genet
; 41(10): 1068-75, 2009 Oct.
Article
em En
| MEDLINE
| ID: mdl-19718027
ABSTRACT
Single-layered embryonic skin either stratifies to form epidermis or responds to Wnt signaling (stabilized beta-catenin) to form hair follicles. Postnatally, stem cells continue to differentially use Wnt signaling in long-term tissue homeostasis. We have discovered that embryonic progenitor cells and postnatal hair follicle stem cells coexpress Tcf3 and Tcf4, which can act as transcriptional activators or repressors. Using loss-of-function studies and transcriptional analyses, we uncovered consequences to the absence of Tcf3 and Tcf4 in skin that only partially overlap with those caused by beta-catenin deficiency. We established roles for Tcf3 and Tcf4 in long-term maintenance and wound repair of both epidermis and hair follicles, suggesting that Tcf proteins have both Wnt-dependent and Wnt-independent roles in lineage determination.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Transdução de Sinais
/
Células Epiteliais
/
Fatores de Transcrição TCF
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Homeostase
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Proteínas do Tecido Nervoso
Limite:
Animals
Idioma:
En
Revista:
Nat Genet
Assunto da revista:
GENETICA MEDICA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos