No involvement of alpha 2-adrenoceptors in the regulation of basal prolactin secretion in healthy men.
Psychoneuroendocrinology
; 15(2): 125-9, 1990.
Article
em En
| MEDLINE
| ID: mdl-1972797
ABSTRACT
The role of alpha 2-adrenoceptors in the regulation of basal prolactin secretion was investigated in healthy male volunteers. Two independent, placebo-controlled, double-blind experiments were performed. In the first experiment, 50 micrograms dexmedetomidine (MPV-1440), a selective alpha 2-adrenoceptor agonist, and saline placebo were infused (IV) in five subjects. In the second experiment, 100 mg atipamezole (MPV-1248), a selective alpha 2-adrenoceptor antagonist, and saline placebo were infused in six volunteers. The concentrations of prolactin in plasma were not affected by the drugs. These results suggest that alpha 2-adrenoceptors do not a play significant role in the control of basal prolactin secretion in healthy men.
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Base de dados:
MEDLINE
Assunto principal:
Prolactina
/
Receptores Adrenérgicos alfa
/
Agonistas alfa-Adrenérgicos
/
Imidazóis
Tipo de estudo:
Clinical_trials
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Psychoneuroendocrinology
Ano de publicação:
1990
Tipo de documento:
Article
País de afiliação:
Finlândia