[Biocompatibility of new bone tissue engineering scaffolds in vivo].
Hua Xi Kou Qiang Yi Xue Za Zhi
; 27(4): 447-50, 2009 Aug.
Article
em Zh
| MEDLINE
| ID: mdl-19769271
ABSTRACT
OBJECTIVE:
To investigate the biocompatibility of new bone tissue engineering scaffolds, AD, L-polylactic acid (PDLLA)/polylactic acid-polyethylene glycol-polylactic acid-polylactic acid (PLA-PEG-PLA)/Tricalcium phosphate and B PDLLA/PLA-PEG-PLA in vivo, compared with PDLLA in repair of a rabbit mandibular body defect.METHODS:
24 New Zealand adult rabbits were divided into 4 groups randomly. 15 mm x 6 mm defects were made surgically in the bilateral mandibular bodies and each hemi-mandible was assigned as an experimental unit. The defects were randomly repaired with scaffold materials in each group. Specimens obtained were evaluated with general observation, X-ray, histomorphology and computerized graphical analysis at 2, 4 , 8, 12 weeks after surgery.RESULTS:
Compared with PDLLA, the new scaffold materials B showed biocompatibility. At the same time the quantity of new bone produced was much more than that in control group (P<0.05). The new scaffold materials A showed the clear chronic granulomatous inflammation.CONCLUSION:
New scaffold material B had sound biocompatibility. It was much better than PDLLA. So it may be an ideal bone tissue engineering scaffold material. A is not adapted to be used as scaffold material.
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Base de dados:
MEDLINE
Assunto principal:
Materiais Biocompatíveis
/
Engenharia Tecidual
Limite:
Animals
Idioma:
Zh
Revista:
Hua Xi Kou Qiang Yi Xue Za Zhi
Assunto da revista:
ODONTOLOGIA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
China