[Preparation and characterization of solid dispersions of ginkgolides].
Zhongguo Zhong Yao Za Zhi
; 34(11): 1368-72, 2009 Jun.
Article
em Zh
| MEDLINE
| ID: mdl-19771864
ABSTRACT
OBJECTIVE:
To optimize the preparation process of solid dispersions of ginkgolides to improve the drug dissolution.METHOD:
The influence of formulation and preparation technology on drug release from solid dispersions was investigated by single factor test. The X-ray diffraction analysis (XRD) and differential scanning calorimetry (DSC) were used to characterize the solid dispersions of ginkgolides.RESULT:
The solubilization efficiency of solid dispersions using PVP k30 as carrier was better than that taking poloxamer 188 or HPMC as matrix. The results of XRD and DSC showed that ginkgolides existed in solid dispersion at amorphous form or solvates form. The dissolution rate of ginkgolide B in solid dispersion was increased dramatically compared with raw material.CONCLUSION:
Solid dispersions could significantly improve solubility and dissolution rate of ginkgolides.
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Base de dados:
MEDLINE
Assunto principal:
Preparações Farmacêuticas
/
Ginkgolídeos
Idioma:
Zh
Revista:
Zhongguo Zhong Yao Za Zhi
Assunto da revista:
FARMACOLOGIA
/
TERAPIAS COMPLEMENTARES
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
China