A new antimicrobial fatty acid from the calcareous sponge Paragrantia cf. waguensis.
Chem Biodivers
; 6(9): 1374-7, 2009 Sep.
Article
em En
| MEDLINE
| ID: mdl-19774600
ABSTRACT
A new acetylenic fatty acid, 1, has been isolated from the title sponge. The structure of the molecule was elucidated to contain an enyne and a thiophene by spectroscopic methods. Compound 1 showed a weak cytotoxic effect against NBT-T2 rat bladder epithelial cells (IC(50) > 20 microg/ml), and antimicrobial activity with minimal-inhibitory concentrations (MIC) of 64 and 128 microg/ml against Staphylococcus aureus and Escherichia coli, respectively.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Poríferos
/
Tiofenos
/
Ácidos Graxos Insaturados
/
Anti-Infecciosos
Limite:
Animals
Idioma:
En
Revista:
Chem Biodivers
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Japão