Bone marrow-derived cells from male donors can compose endometrial glands in female transplant recipients.
Am J Obstet Gynecol
; 201(6): 608.e1-8, 2009 Dec.
Article
em En
| MEDLINE
| ID: mdl-19800602
ABSTRACT
OBJECTIVE:
For continuous regeneration of human endometrium in menstrual cycles, endometrial stem cells are assumed to supply differentiating endometrial glandular cells. To elucidate the origin of endometrial stem cells, we examined the presence of donor-derived cells in endometria from patients who received bone marrow transplantation from male donors. STUDYDESIGN:
Endometrial specimens biopsied after hormone replacement therapy were obtained and examined using fluorescent in situ hybridization analysis targeting X or Y chromosomes.RESULTS:
All recipients had donor-derived Y chromosome-positive endometrial cells, accounting for 0.6-8.4% of glandular epithelial cells and 8.2-9.8% of stromal cells. Most of the endometrial glands were chimeric, consisting of both donor-derived and recipient cells.CONCLUSION:
Donor-derived cells are capable of composing endometrium in recipients, even those of the opposite sex. These results suggest unexpected plasticity of bone marrow stem cells as well as a potential origin of endometrial stem cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doadores de Tecidos
/
Células da Medula Óssea
/
Transplante de Medula Óssea
/
Endométrio
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Am J Obstet Gynecol
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Japão