Scavenger receptor control of chromogranin A-induced microglial stress and neurotoxic cascades.
FEBS Lett
; 583(21): 3461-6, 2009 Nov 03.
Article
em En
| MEDLINE
| ID: mdl-19800883
ABSTRACT
Chromogranin A (CgA), a neuroactive glycoprotein, is associated with microglial activation cascades implicated in neurodegeneration. Here we show that CgA-dependent inducible nitric oxide synthase (iNOS) expression and stress responses in microglia involved signalling via scavenger receptors (SR), since SR class-A (SR-A) ligands blocked iNOS expression, mitochondrial depolarisation, apoptosis and glutamate release. Furthermore, block of SR-A ameliorated CgA-induced microglial neurotoxicity. In contrast, block of CD36, or the receptor for advanced glycation end products (RAGE) did not prevent CgA-induced microglial activation and neurotoxicity. Thus, manipulation of specific scavenger receptor-coupled signalling pathways may provide avenues for therapeutic intervention in neurodegenerative diseases implicating microglial activation with chromogranin peptides.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Microglia
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Receptores Depuradores
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Cromogranina A
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Neurotoxinas
Limite:
Animals
Idioma:
En
Revista:
FEBS Lett
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Reino Unido