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Heat shock proteins induce pores in membranes.
Alder, G M; Austen, B M; Bashford, C L; Mehlert, A; Pasternak, C A.
Afiliação
  • Alder GM; Department of Cellular and Molecular Sciences, St George's Hospital Medical School, London.
Biosci Rep ; 10(6): 509-18, 1990 Dec.
Article em En | MEDLINE | ID: mdl-1982226
Human heat shock protein (hsp) 70 and bacterial protein groEL promote leakage of calcein from liposomes induced by human serum albumin signal peptide, by S. aureus alpha toxin or by diphtheria toxin. Hsp 70 and groEL, as well as two mycobacterial homologues hsp 71 and hsp 65, induce ion conducting pores across planar lipid bilayers at low or neutral pH. It is concluded that hsp induce pores in membranes and that this may contribute to their action within cells.
Assuntos
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Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Ativação do Canal Iônico / Fluoresceínas / Proteínas de Choque Térmico Idioma: En Revista: Biosci Rep Ano de publicação: 1990 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Proteínas de Bactérias / Ativação do Canal Iônico / Fluoresceínas / Proteínas de Choque Térmico Idioma: En Revista: Biosci Rep Ano de publicação: 1990 Tipo de documento: Article