Discovery of the first known small-molecule inhibitors of heme-regulated eukaryotic initiation factor 2alpha (HRI) kinase.
Bioorg Med Chem Lett
; 19(23): 6548-51, 2009 Dec 01.
Article
em En
| MEDLINE
| ID: mdl-19854648
ABSTRACT
A series of indeno[1,2-c]pyrazoles were discovered to be the first known inhibitors of heme-regulated eukaryotic initiation factor 2alpha (HRI) kinase. The synthesis, structure-activity relationship profile, and in-vitro pharmacological characterization of this inaugural series of HRI kinase inhibitors are detailed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirazóis
/
EIF-2 Quinase
/
Inibidores de Proteínas Quinases
/
Descoberta de Drogas
/
Heme
/
Indenos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos