Autophagy as the main means of cytotoxicity by glucocorticoids in hematological malignancies.
Autophagy
; 5(8): 1198-200, 2009 Nov.
Article
em En
| MEDLINE
| ID: mdl-19855186
ABSTRACT
Glucocorticoids are fundamental drugs used in the treatment of lymphoid malignancies with apoptotic cell death as the hitherto proposed mechanism of action. We have recently shown that dexamethasone induces autophagy in lymphoid leukemia cells and in this particular setting this cell death modality is a prerequisite for the efficient killing of the leukemic cells by dexamethasone. Hence, inhibition of autophagy by siRNA-mediated silencing of Beclin 1, as well as chemical inhibition of type III PtdIns3K, inhibits apoptosis, demonstrating an important role of autophagy in dexamethasone-induced cell death. In this brief report, we review these findings and introduce the multiple myeloma cells as a novel system to study autophagy in response to dexamethasone.
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Base de dados:
MEDLINE
Assunto principal:
Autofagia
/
Dexametasona
/
Apoptose
/
Neoplasias Hematológicas
/
Glucocorticoides
Limite:
Humans
Idioma:
En
Revista:
Autophagy
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Suécia