Lodopyridone, a structurally unprecedented alkaloid from a marine actinomycete.
Org Lett
; 11(23): 5422-4, 2009 Dec 03.
Article
em En
| MEDLINE
| ID: mdl-19883103
ABSTRACT
Chemical examination of the secondary metabolites of a marine Saccharomonospora sp., isolated from marine sediments collected at the mouth of the La Jolla Submarine Canyon, yielded the unprecedented alkaloid lodopyridone (1). The low proton-to-carbon ratio of 1 precluded structure elucidation by NMR spectroscopic methods, thus the structure was defined by X-ray crystallography. Lodopyridone is cytotoxic to HCT-116 human colon cancer cells with IC(50) = 3.6 microM.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Actinobacteria
/
Alcaloides
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Org Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos