2-Arylbenzoxazoles as CETP inhibitors: Substitution of the benzoxazole moiety.
Bioorg Med Chem Lett
; 20(1): 346-9, 2010 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-19914065
ABSTRACT
A series of 2-arylbenzoxazole inhibitors of the cholesterol ester transfer protein (CETP) is described. Structure-activity studies focused on variation of the substitution of the benzoxazole moiety. Substitution at the 5- and 7-positions of the benzoxazole moiety was found to be beneficial for CETP inhibition. Compound 47 was found to be the most potent inhibitor in this series and inhibited CETP with an IC(50) of 28nM.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Benzoxazóis
/
Proteínas de Transferência de Ésteres de Colesterol
/
Acetanilidas
/
Anticolesterolemiantes
Limite:
Animals
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos