Is there a prognostic role for C-reactive protein in ischemic stroke?
Acta Neurol Scand
; 122(3): 209-16, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-19925530
ABSTRACT
OBJECTIVES:
We investigated the relationship between C-reactive protein (CRP)-values in the acute phase of stroke and the risk of further fatal and non-fatal ischemic events. MATERIALS ANDMETHODS:
We analysed 462 consecutive incident ischemic strokes. Patients were divided into two subgroups on the basis of a CRP cut-off level of 9 mg/l. Primary end points were any new vascular fatal and non-fatal event recorded during the follow-up period.RESULTS:
During a follow-up of 2.27 years, in 132 patients occurred a primary end point. Patients with CRP values > or = 9 mg/l had more frequently primary end point. The hazard ratio (HR) for cardiovascular events was 3.59; 1.93 for cerebrovascular events; 7.43 for vascular deaths and 5.78 for death from any cause. Cox proportional hazard multivariate analysis identified CRP values > or = 9 (HR = 4.19, 95% CI 1.85-9.50, P = 0.001), the lack of secondary prevention therapy at discharge (HR = 4.35, 95% CI 1.87-10.1, P = 0.001), age >70 years (HR = 3.09, 95% CI 1.04-9.24, P = 0.04) as independent predictors of fatal events.CONCLUSIONS:
CRP levels > or = 9 mg/l, evaluated in incident ischemic stroke within 24 h, predict a higher risk of further ischemic events and mortality.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteína C-Reativa
/
Acidente Vascular Cerebral
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Acta Neurol Scand
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Itália