Effect of angiotensin-converting enzyme inhibitor on matrix metalloproteinase-9 activity in patients with Kawasaki disease.
Clin Chim Acta
; 411(3-4): 267-9, 2010 Feb.
Article
em En
| MEDLINE
| ID: mdl-19945447
ABSTRACT
BACKGROUND:
Matrix metalloproteinase (MMP)-9 is thought to be involved in coronary artery aneurysms (CAAs) in patients with Kawasaki disease (KD); however, MMP-9 inhibitors are not used clinically. This study investigated whether the angiotensin-converting enzyme (ACE) inhibitor captopril could inhibit serum MMP-9 activity using serum from KD patients in an in vitro experiment.METHODS:
In 7 KD patients, serum MMP-9 activity was measured using the MMP-9 assay kit 3 times before and after intravenous immunoglobulin (IVIG) treatment, and during the convalescent phase. The effect of captopril on MMP-9 activity was also assessed using serum obtained before IVIG treatment.RESULTS:
Serum MMP-9 activity was significantly higher during the pre-treatment phase than during the post-treatment and convalescent phases. MMP-9 activity during the pre-treatment phase was dose-dependently inhibited by captopril, and the IC(50) for MMP-9 was 500nM. The potency of captopril for MMP-9 inhibition was comparable to that for ACE inhibition.CONCLUSION:
ACE inhibitor may be effective for preventing CAA formation in KD patients, especially IVIG non-responders.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Inibidores da Enzima Conversora de Angiotensina
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Captopril
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Peptidil Dipeptidase A
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Metaloproteinase 9 da Matriz
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Síndrome de Linfonodos Mucocutâneos
Limite:
Child
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Child, preschool
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Female
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Humans
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Infant
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Male
Idioma:
En
Revista:
Clin Chim Acta
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Japão