Your browser doesn't support javascript.
loading
Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum.
Tang, Jian; Li, Hui-Liang; Shen, Yun-Heng; Jin, Hui-Zi; Yan, Shi-Kai; Liu, Xiao-Hua; Zeng, Hua-Wu; Liu, Run-Hui; Tan, Ye-Xiong; Zhang, Wei-Dong.
Afiliação
  • Tang J; School of Pharmacy, Shanghai Jiao Tong University, Shanghai, PR China.
Phytother Res ; 24(6): 821-6, 2010 Jun.
Article em En | MEDLINE | ID: mdl-20013819
ABSTRACT
Ten steroidal alkaloids - cyclopamine, veratramine, jervine, 3, 15-diangyloylgermine, 3-angyloylzygadenine, 3-veratroyl zygadenine, 15-veratroylgermine, germine, veratrosine and pseudojervine - from Veratrum dahuricum, together with the ethanol extract and total alkaloids, were evaluated for their antitumor and antiplatelet activities. Cyclopamine, veratramine and germine significantly inhibited the hedgehog pathway in NIH/3T3 cells. Cyclopamine exerted a potent inhibitory effect against the growth of PANC-1 tumors in mice, with inhibition rates of 40.64%, 44.37%, 46.77% at doses of 5.0, 15.0 and 50.0 mg kg-1, respectively. Veratroylgermine was found to produce the strongest inhibition against the platelet aggregation induced by arachidonic acid, with inhibition rate of 92.0% at 100 microM.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Veratrum / Alcaloides de Veratrum / Inibidores da Agregação Plaquetária / Extratos Vegetais / Antineoplásicos Fitogênicos Limite: Animals Idioma: En Revista: Phytother Res Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2010 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Veratrum / Alcaloides de Veratrum / Inibidores da Agregação Plaquetária / Extratos Vegetais / Antineoplásicos Fitogênicos Limite: Animals Idioma: En Revista: Phytother Res Assunto da revista: TERAPIAS COMPLEMENTARES Ano de publicação: 2010 Tipo de documento: Article