Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum.
Phytother Res
; 24(6): 821-6, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20013819
ABSTRACT
Ten steroidal alkaloids - cyclopamine, veratramine, jervine, 3, 15-diangyloylgermine, 3-angyloylzygadenine, 3-veratroyl zygadenine, 15-veratroylgermine, germine, veratrosine and pseudojervine - from Veratrum dahuricum, together with the ethanol extract and total alkaloids, were evaluated for their antitumor and antiplatelet activities. Cyclopamine, veratramine and germine significantly inhibited the hedgehog pathway in NIH/3T3 cells. Cyclopamine exerted a potent inhibitory effect against the growth of PANC-1 tumors in mice, with inhibition rates of 40.64%, 44.37%, 46.77% at doses of 5.0, 15.0 and 50.0 mg kg-1, respectively. Veratroylgermine was found to produce the strongest inhibition against the platelet aggregation induced by arachidonic acid, with inhibition rate of 92.0% at 100 microM.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Veratrum
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Alcaloides de Veratrum
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Inibidores da Agregação Plaquetária
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Extratos Vegetais
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Antineoplásicos Fitogênicos
Limite:
Animals
Idioma:
En
Revista:
Phytother Res
Assunto da revista:
TERAPIAS COMPLEMENTARES
Ano de publicação:
2010
Tipo de documento:
Article