De novo formation of basal bodies during cellular differentiation of Naegleria gruberi: progress and hypotheses.
Semin Cell Dev Biol
; 21(2): 156-62, 2010 Apr.
Article
em En
| MEDLINE
| ID: mdl-20035893
ABSTRACT
Under defined laboratory conditions, Naegleria gruberi undergo an amoeba-to-flagellate differentiation. During this differentiation, N. gruberi changes its shape from an amorphous amoeba to a regular shaped flagellate and forms de novo a flagellar apparatus, which is composed of two basal bodies, two flagella, a flagellar rootlet, and cytoplasmic microtubules. The entire process is accomplished within 2h after initiation of differentiation and more than 95% of cells in the population undergo this differentiation. This rapid and synchronous differentiation of N. gruberi provides us with a unique system in which we can study the process of de novo basal body assembly. In this review, I summarize recent findings associated with de novo basal body assembly and propose a hypothesis to explain how N. gruberi assemble two basal bodies per cell, which is what happens in the majority of cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Naegleria
/
Centríolos
Limite:
Animals
Idioma:
En
Revista:
Semin Cell Dev Biol
Assunto da revista:
EMBRIOLOGIA
Ano de publicação:
2010
Tipo de documento:
Article