Eukaryotic cold shock domain proteins: highly versatile regulators of gene expression.
Bioessays
; 32(2): 109-18, 2010 Feb.
Article
em En
| MEDLINE
| ID: mdl-20091748
ABSTRACT
Cold shock domain (CSD)-containing proteins have been found in all three domains of life and function in a variety of processes that are related, for the most part, to post-transcriptional gene regulation. The CSD is an ancient beta-barrel fold that serves to bind nucleic acids. The CSD is structurally and functionally similar to the S1 domain, a fold with otherwise unrelated primary sequence. The flexibility of the CSD/S1 domain for RNA recognition confers an enormous functional versatility to the proteins that contain them. This review summarizes the current knowledge on eukaryotic CSD/S1 domain-containing proteins with a special emphasis on UNR (upstream of N-ras), a member of this family with multiple copies of the CSD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fatores de Iniciação em Eucariotos
/
Células Eucarióticas
/
Proteínas de Choque Térmico
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Bioessays
Assunto da revista:
BIOLOGIA
/
BIOLOGIA MOLECULAR
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Espanha