Decreased kidney function of unknown cause in Nicaragua: a community-based survey.
Am J Kidney Dis
; 55(3): 485-96, 2010 Mar.
Article
em En
| MEDLINE
| ID: mdl-20116154
ABSTRACT
BACKGROUND:
End-stage kidney disease overwhelms health services in Central America. We determined prevalences of decreased kidney function in distinct populations in the most affected region of Nicaragua. STUDYDESIGN:
Cross-sectional survey. SETTING &PARTICIPANTS:
Total populations aged 20-60 years of 5 villages in Northwest Nicaragua mining/subsistence farming (elevation, 100-300 m above sea level), banana/sugarcane (100-300 m), fishing (0-100 m), services (0-100 m), and coffee (200-675 m); 479 men and 617 women (83% response). PREDICTOR OR FACTOR Village; participant sex, age, and occupation; conventional chronic kidney disease risk factors.OUTCOMES:
Serum creatinine (SCr) values greater than laboratory reference range for sex, estimated glomerular filtration rate <60 mL/min/1.73 m(2), proteinuria stratified in the low (dipstick protein excretion, 30-300 mg/dL) and high (>300 mg/dL) range.RESULTS:
Prevalences of abnormal SCr levels 18% (of all men) and 5% (of all women); in the mining/subsistence farming village, 26% and 7%; banana/sugarcane, 22% and 6%; fishing, 13% and 4%; services, 0% and 1%; and coffee, 7% and 0%. Prevalences of estimated glomerular filtration rate <60 mL/min/1.73 m(2) 14% (of all men) and 3% (of all women); in the listed villages, 19% and 5%, 17% and 4%, 10% and 2%, 0% and 0%, and 7% and 0%, respectively. Proteinuria, predominantly in the low range, affected 14% and 11% of all men and women without marked differences between villages. By occupation, abnormal SCr levels occurred in 31% and 24% of male and female agricultural workers at 100-300 m above sea level, but not at higher altitudes, and also was high in male artisans (43%), construction workers (15%), and miners (14%). In logistic regression models, for the banana/sugarcane and mining/subsistence farming villages, high blood pressure and age were significant predictors of abnormal SCr levels in men, and for mining/subsistence farming, age in women.LIMITATIONS:
Causality is not addressed.CONCLUSIONS:
In some Nicaraguan villages and population segments, men in particular show a high prevalence of decreased kidney function of unknown origin, possibly environmental or occupational.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nefropatias
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
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Male
/
Middle aged
País/Região como assunto:
America central
/
Nicaragua
Idioma:
En
Revista:
Am J Kidney Dis
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Nicarágua