Respiratory compliance in preterm infants after a single rescue course of antenatal steroids: a randomized controlled trial.
Am J Obstet Gynecol
; 202(6): 544.e1-9, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20227053
ABSTRACT
OBJECTIVE:
To compare respiratory compliance and functional residual capacity in infants randomized to a rescue course of antenatal steroids vs placebo. STUDYDESIGN:
Randomized, double-blinded trial. Pregnant women > or =14 days after initial antenatal steroids were randomized to rescue antenatal steroids or placebo. The primary outcomes were measurements of respiratory compliance and functional residual capacity. This study is registered with clinicaltrials.gov (NCT00669383).RESULTS:
Forty-four mothers (56 infants) received rescue antenatal steroids and 41 mothers (57 infants) received placebo. There was no significant difference in birthweight, or head circumference. Infants in the rescue group had an increased respiratory compliance (1.21 vs 1.01 mL/cm H(2)O/kg; adjusted 95% confidence interval, 0.01-0.49; P = .0433) compared with placebo. 13% in the rescue vs 29% in the placebo group required > or =30% oxygen (P < .05). Patients delivered at < or =34 weeks had greater pulmonary benefits.CONCLUSION:
Infants randomized to rescue antenatal steroids have a significantly increased respiratory compliance compared with placebo.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Síndrome do Desconforto Respiratório do Recém-Nascido
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Betametasona
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Mecânica Respiratória
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Capacidade Residual Funcional
Tipo de estudo:
Clinical_trials
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Observational_studies
Limite:
Female
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Humans
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Male
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Newborn
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Pregnancy
Idioma:
En
Revista:
Am J Obstet Gynecol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos