Response of vitamin B-6 content of muscle to changes in vitamin B-6 intake in men.
Am J Clin Nutr
; 53(6): 1436-42, 1991 Jun.
Article
em En
| MEDLINE
| ID: mdl-2035470
ABSTRACT
Previous reports indicated that in growing rats the vitamin B-6 pool in muscle was relatively stable during deficiency but increased in response to increased vitamin B-6 intake. To determine whether human muscle would show a similar response 10 college-aged males received a low vitamin B-6 diet (1.76 mumol/d) for 6 wk followed by 6 wk on a self-selected diet supplemented with 0.98 mmol pyridoxine HCl/d. During depletion, excretion of pyridoxic acid rapidly adjusted to approximate the intake. Plasma pyridoxal phosphate concentrations at the end of the baseline, depletion, and supplementation periods were 81 +/- 51, 9 +/- 3, and 455 +/- 129 nmol/L, respectively, whereas muscle concentrations were 21 +/- 9, 20 +/- 4, and 25 +/- 7 nmol/g, respectively and total vitamin B-6 in muscle was 28 +/- 10, 27 +/- 4, and 35 +/- 10 nmol/g, respectively. These data provide further confirmation that the vitamin B-6 pools in skeletal muscle are resistant to depletion. They also demonstrate that in humans with constant body weight, vitamin B-6 supplementation is not associated with marked increases in vitamin B-6 in muscle.
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Base de dados:
MEDLINE
Assunto principal:
Piridoxina
/
Músculos
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Am J Clin Nutr
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Índia