[Study of cognitive function and brain volume in type 2 diabetic patients].
Zhonghua Yi Xue Za Zhi
; 90(5): 327-31, 2010 Feb 02.
Article
em Zh
| MEDLINE
| ID: mdl-20368055
ABSTRACT
OBJECTIVE:
To investigate the differences of cognitive function and brain volume between patients with type 2 diabetes mellitus (DM) and healthy controls.METHODS:
Multi-dimensional neuropsychological tests were employed to evaluated cognitive function in 21 type 2 DM patients and 19 healthy controls, and voxel-based morphometry method was applied to measure volume of whole and regional gray matter in brain of these subjects.RESULTS:
Compared to healthy controls [(7.3 +/- 1.4), (22.7 +/- 1.2), (9.5 +/- 2.5) respectively], significantly impaired performance of Auditory Verbal Learning Test (AVLT)-Delay Recall, [(5.7 +/- 1.8)] AVLT-Recognition [(20.8 +/- 2.6)] and Clock Drawing Test (CDT) [(8.0 +/- 1.1)] and extensive atrophy of gray matter (after corrected by total intracranial volume) were observed in type 2 DM patients (P < 0.05). In addition, whole gray matter/Total Intracranial Volume (TIV) was significantly negatively correlated with BMI (r = -0.352, P = 0.013). And negative correlations existed between whole gray matter vs HbA1c (r = -0.309, P = 0.026); the performance of AVLT-Delay Recall and AVLT-Recognition vs BMI (r = -0.398, P = 0.011; r = -0.4, P = 0.011)and HbA1c (r = -0.354, P = 0.025; r = -0.323, P = 0.042) and CDT vs HbA1c (r = -0.322, P = 0.043).CONCLUSION:
Multi-cognitive impairment was associated with the reduced volume of whole and regional gray matter in brain of type 2 DM patients, which indicated that "accelerated brain ageing" might present in type 2 DM patients.
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Base de dados:
MEDLINE
Assunto principal:
Transtornos Cognitivos
/
Diabetes Mellitus Tipo 2
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Yi Xue Za Zhi
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
China