Black fly salivary gland extract inhibits proliferation and induces apoptosis in murine splenocytes.
Parasite Immunol
; 32(4): 275-84, 2010 Apr.
Article
em En
| MEDLINE
| ID: mdl-20398228
ABSTRACT
Black flies are known to be vectors of pathogens including Onchocerca volvulus, which causes human onchocerciasis, and Vesicular Stomatitis Virus. Their salivary secretion has been shown to contain a complex cocktail of anti-haemostatic factors and immunomodulatory activities, which may contribute to efficient transmission of the pathogens. Black fly salivary gland extract (SGE) inhibits mitogen-stimulated mouse splenocyte proliferation, including proliferation of both CD4(+) and CD8(+) T cells. The factor responsible for the inhibition was determined to be a protein (or protein complex) of a size larger than 50 kDa. Moreover, exposure to SGE results in activation of caspase 3 and characteristic morphological changes in CD4(+) and CD8(+) T cells, suggesting that induction of apoptosis could, at least in part, be responsible for this inhibition.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Glândulas Salivares
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Proteínas e Peptídeos Salivares
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Simuliidae
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Leucócitos Mononucleares
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Apoptose
Limite:
Animals
Idioma:
En
Revista:
Parasite Immunol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos