Vaccines based on abnormal self-antigens as tumor-associated antigens: immune regulation.
Semin Immunol
; 22(3): 125-31, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20403708
ABSTRACT
Abnormal expression of "self" antigens on tumors compared with normal cells provides opportunities and challenges for development of cancer vaccines. We review recent work in pre-clinical transgenic mouse models and in clinical trials that has elucidated multiple regulatory mechanisms that interfere with the induction of effective immunity. We discuss these as being either part of the normal function of the immune system or being driven by the tumor microenvironment. Collectively this work shows that it is possible to design vaccines based on tumor-associated antigens and elicit effective immunity against abnormal expression of these antigens on tumors without causing autoimmunity.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autoantígenos
/
Vacinas Anticâncer
/
Antígenos de Neoplasias
/
Neoplasias
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Semin Immunol
Assunto da revista:
ALERGIA E IMUNOLOGIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos