Lower frequency of the low activity adenosine deaminase allelic variant (ADA1*2) in schizophrenic patients.
Braz J Psychiatry
; 32(3): 275-8, 2010 Sep.
Article
em En
| MEDLINE
| ID: mdl-20414589
ABSTRACT
OBJECTIVE:
Adenosine may play a role in the pathophysiology of schizophrenia, since it modulates the release of several neurotransmitters such as glutamate, dopamine, serotonin and acetylcholine, decreases neuronal activity by pos-synaptic hyperpolarization and inhibits dopaminergic activity. Adenosine deaminase participates in purine metabolism by converting adenosine into inosine. The most frequent functional polymorphism of adenosine deaminase (22GâA) (ADA1*2) exhibits 20-30% lower enzymatic activity in individuals with the G/A genotype than individuals with the G/G genotype. The aim of this study was to evaluate the ADA polymorphism 22GâA (ADA1*2) in schizophrenic patients and healthy controls.METHOD:
The genotypes of the ADA 22GâA were identified with allele-specific PCR strategy in 152 schizophrenic patients and 111 healthy individuals.RESULTS:
A significant decrease in the frequency of the G/A genotype was seen in schizophrenic patients (7/152 - 4.6%) relative to controls (13/111 - 11.7%, p = 0.032, OR = 2.6).CONCLUSION:
These results suggest that the G/A genotype associated with low adenosine deaminase activity and, supposingly, with higher adenosine levels is less frequent among schizophrenic patients.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polimorfismo Genético
/
Esquizofrenia
/
Adenosina Desaminase
/
Frequência do Gene
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Braz J Psychiatry
Assunto da revista:
PSIQUIATRIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Brasil