Synthesis and biological evaluation of new 5-fluorouracil-substituted ampelopsin derivatives.
Molecules
; 15(4): 2114-23, 2010 Mar 24.
Article
em En
| MEDLINE
| ID: mdl-20428031
ABSTRACT
This study reports two novel 5-fluorouracil-substituted ampelopsin derivatives. The structures of two new derivatives were characterized by elemental analysis, 1H-NMR, 13C-NMR, IR and MS. Their anticancer activities in vitro against two cancer cell lines, K562 and K562/ADR, were investigated using the MTT assay, and the results showed that the two new compounds were more effective than reference drugs such as ampelopsin and verapamil.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Flavonoides
/
Flavanonas
/
Fluoruracila
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Revista:
Molecules
Assunto da revista:
BIOLOGIA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
China