Histologic and receptor analysis of primary and secondary vestibulodynia and controls: a prospective study.
Am J Obstet Gynecol
; 202(6): 614.e1-8, 2010 Jun.
Article
em En
| MEDLINE
| ID: mdl-20430353
ABSTRACT
OBJECTIVE:
The objective of the study was to assess the association between hormone receptor densities, pain nerves, and inflammation in vestibulodynia patients. STUDYDESIGN:
In a prospective study, tender and nontender biopsies from 10 primary and 10 secondary vestibulodynia patients were compared with biopsies in 4 nontender controls. Hormone receptors were evaluated using immunohistochemistry for estrogen receptor-alpha and -beta, androgen, and progesterone receptors. Inflammation, nerves, and mast cells were assessed histologically. Statistical analysis was by Fisher's exact test, analysis of variance, paired Student t test, and Wilcoxon rank test.RESULTS:
Tender sites from primary vestibulodynia had increased nerve density compared with secondary and control biopsies (P = .01). Tender sites in secondary vestibulodynia had more lymphocytes than tender primary sites and control biopsies (P < .0001). Mast cells were increased in tender sites compared with nontender and controls. There were no differences in hormone receptor expression.CONCLUSION:
Markers of inflammation differed between primary and secondary vestibulodynia and controls.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vulvodinia
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Middle aged
Idioma:
En
Revista:
Am J Obstet Gynecol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos