SensSB: a software toolbox for the development and sensitivity analysis of systems biology models.
Bioinformatics
; 26(13): 1675-6, 2010 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-20444837
ABSTRACT
SUMMARY:
SensSB (Sensitivity Analysis for Systems Biology) is an easy to use, MATLAB-based software toolbox, which integrates several local and global sensitivity methods that can be applied to a wide variety of biological models. In addition to addressing the sensitivity analysis problem, SensSB aims to cover all the steps involved during the modeling process. The main features of SensSB are (i) derivative and variance-based global sensitivity analysis, (ii) pseudo-global identifiability analysis, (iii) optimal experimental design (OED) based on global sensitivities, (iv) robust parameter estimation, (v) local sensitivity and identifiability analysis, (vi) confidence intervals of the estimated parameters and (vii) OED based on the Fisher Information Matrix (FIM). SensSB is also able to import models in the Systems Biology Mark-up Language (SBML) format. Several examples from simple analytical functions to more complex biological pathways have been implemented and can be downloaded together with the toolbox. The importance of using sensitivity analysis techniques for identifying unessential parameters and designing new experiments is quantified by increased identifiability metrics of the models and decreased confidence intervals of the estimated parameters.AVAILABILITY:
SensSB is a software toolbox freely downloadable from http//www.iim.csic.es/ approximately gingproc/SensSB.html. The web site also contains several examples and an extensive documentation. CONTACT mrodriguez@iim.csic.es SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
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Base de dados:
MEDLINE
Assunto principal:
Software
/
Biologia de Sistemas
/
Modelos Biológicos
Tipo de estudo:
Diagnostic_studies
Idioma:
En
Revista:
Bioinformatics
Assunto da revista:
INFORMATICA MEDICA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Espanha