Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes.
Science
; 328(5982): 1158-61, 2010 May 28.
Article
em En
| MEDLINE
| ID: mdl-20448152
ABSTRACT
Obesity results from chronic energy surplus and excess lipid storage in white adipose tissue (WAT). In contrast, brown adipose tissue (BAT) efficiently burns lipids through adaptive thermogenesis. Studying mouse models, we show that cyclooxygenase (COX)-2, a rate-limiting enzyme in prostaglandin (PG) synthesis, is a downstream effector of beta-adrenergic signaling in WAT and is required for the induction of BAT in WAT depots. PG shifted the differentiation of defined mesenchymal progenitors toward a brown adipocyte phenotype. Overexpression of COX-2 in WAT induced de novo BAT recruitment in WAT, increased systemic energy expenditure, and protected mice against high-fat diet-induced obesity. Thus, COX-2 appears integral to de novo BAT recruitment, which suggests that the PG pathway regulates systemic energy homeostasis.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tecido Adiposo Marrom
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Prostaglandinas
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Termogênese
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Metabolismo Energético
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Ciclo-Oxigenase 2
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Tecido Adiposo Branco
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Adipócitos Marrons
Tipo de estudo:
Etiology_studies
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Alemanha