Structural disorder in proteins of the rhabdoviridae replication complex.
Protein Pept Lett
; 17(8): 979-87, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-20450482
ABSTRACT
Rhabdoviridae are single stranded negative sense RNA viruses. The viral RNA condensed by the nucleoprotein (N), the phosphoprotein (P) and the large subunit (L) of the RNA-dependent RNA polymerase are the viral components of the transcription/replication machineries. Both P and N contain intrinsically disordered regions (IDRs) that play different roles in the virus life cycle. Here, we describe the modular organization of P based on recent structural, biophysical and bioinformatics data. We show how flexible loops in N participate in the attachment of P to the N-RNA template by an induced-fit mechanism. Finally, we discuss the roles of IDRs in the mechanism of replication/transcription, and propose a new model for the interaction of the L subunit with its N-RNA template.
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Base de dados:
MEDLINE
Assunto principal:
Fosfoproteínas
/
Rhabdoviridae
/
Replicação Viral
/
Nucleoproteínas
Idioma:
En
Revista:
Protein Pept Lett
Assunto da revista:
BIOQUIMICA
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
França