Importance of TLR2 in the direct response of T lymphocytes to Schistosoma mansoni antigens.
Eur J Immunol
; 40(8): 2221-9, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-20480503
ABSTRACT
The immunomodulatory effect of Schistosoma mansoni antigens has often been attributed to interaction with PRR expressed on APC. Our previous work has shown that S. mansoni-soluble egg antigen (SEA) can induce, together with a Th2 response, TGF-ß-dependent Foxp3 expression in naïve CD4(+) T cells from NOD mice. We found that SEA can directly upregulate the expression of surface-bound TGF-ß in purified CD4(+) T cells in the absence of accessory cell interactions. In this study, we show that the C-type lectin receptors DEC-205 and galectin-3 were involved in the direct interaction between S. mansoni antigens and CD4(+) T cells. SEA was able to enhance CD4(+) T-cell secretion of bioactive TGF-ß in response to TLR2 ligand stimulation, in the absence of APC. We also show that TLR2 expressed on CD4(+) T cells was important for the Foxp3 expression induced by SEA.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Schistosoma mansoni
/
Linfócitos T CD4-Positivos
/
Proteínas de Helminto
/
Fatores de Transcrição Forkhead
/
Receptor 2 Toll-Like
/
Antígenos de Helmintos
Limite:
Animals
Idioma:
En
Revista:
Eur J Immunol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Reino Unido