The effectiveness of packed therapy with three drugs in Helicobacter pylori eradication in Japan.
Methods Find Exp Clin Pharmacol
; 32(4): 243-6, 2010 May.
Article
em En
| MEDLINE
| ID: mdl-20508872
ABSTRACT
Primary Helicobacter pylori eradication rate using triple therapy (a proton pump inhibitor [PPI] + amoxicillin [AMPC] + clarithromycin [CAM], over 7 days) is showing a declining trend. In this study we report recent eradication rates and have evaluated the usefulness of a pack preparation of three drugs. H. pylori eradication rate was 85.1% (57/67) in 2004 but then fell to 75.2% (79/105) in 2005, 70.1% (68/97) in 2006 and 69.9% (58/83) in 2007. With the introduction of packs (lansoprazole [LPZ] 60 mg, AMPC 1500 mg, CAM 400 mg) the eradication rate recovered to 78.0% (110/141) in 2008. A comparative study in 2008 delineated that the eradication rate in the pack group (88.4%, 38/43) was significantly higher than that of the conventional group (73.5%, 72/98). These results suggest that packs of eradication medicine are useful in increasing eradication success.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções por Helicobacter
/
Claritromicina
/
2-Piridinilmetilsulfinilbenzimidazóis
/
Amoxicilina
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Methods Find Exp Clin Pharmacol
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Japão