Is obesity associated with an increased risk for airway hyperresponsiveness and development of asthma?
Allergy Asthma Clin Immunol
; 4(2): 51-8, 2008 Jun 15.
Article
em En
| MEDLINE
| ID: mdl-20525125
ABSTRACT
We investigated the association between airway hyperresponsiveness (AHR) and obesity in adults referred for confirmation of asthma diagnosis. Data were analyzed for obesity class I (body mass index [BMI] 30-34.9 kg/m2), class II (BMI >/= 35-39.9 kg/m2), and class III (BMI >/= 40 kg/m2). Of 861 subjects, 401 demonstrated AHR; the mean dose of methacholine was 4.16 +/- 2.55 mg/mL. A significant association between obesity and AHR was evident for all subjects:
the odds ratio was 1.37 (95% CI 1.02-1.82; p = .0317). One unit of increased BMI (1 kg/m2) was associated with a 3.1% increase in AHR risk (95% CI 1.01-1.05, p < .005). The odds ratio increased from 1.86 (95% CI 1.27-1.76; p = .0012) for class I to 2.61 (95% CI 1.48-4.60; p = .0006) for class III. Obesity was found to be associated with AHR and appears to be a risk factor for asthma.
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Base de dados:
MEDLINE
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Idioma:
En
Revista:
Allergy Asthma Clin Immunol
Ano de publicação:
2008
Tipo de documento:
Article