Fetal dopamine receptor characteristics assessed in utero.
J Cereb Blood Flow Metab
; 30(8): 1437-40, 2010 Aug.
Article
em En
| MEDLINE
| ID: mdl-20531464
ABSTRACT
Any tracer in fetal tissue comes from maternal arterial blood. Provided steady state is achieved and intermediate compartments are reversible, the Logan graphical methods should be applicable to the assessment of binding parameters in the fetal brain. Two pregnant rhesus macaques were studied with fallypride and the Logan method was used to assess dopamine receptor distribution volume ratios (DVRs) in both maternal and fetal striatum. The agreement between fetal striatal DVRs using maternal arterial blood and maternal and fetal cerebellum as input functions strongly supports our hypothesis that the conditions necessary for graphical analysis have been met.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirrolidinas
/
Benzamidas
/
Receptores Dopaminérgicos
/
Corpo Estriado
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Tomografia por Emissão de Pósitrons
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Feto
Limite:
Animals
/
Pregnancy
Idioma:
En
Revista:
J Cereb Blood Flow Metab
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Estados Unidos