Morphological changes of isolated rat liver mitochondria during Fe2+/ascorbate-induced peroxidation and the effect of thioctacid.
Mech Ageing Dev
; 57(3): 233-46, 1991 Mar.
Article
em En
| MEDLINE
| ID: mdl-2056778
ABSTRACT
Fe2+/ascorbate-induced peroxidation of isolated rat liver mitochondria leads to initial volume changes and, ultimately, to severe damage characterized by gross swelling and loss of cristae and matrix material. Only the last phase is associated with significant production of malondialdehyde. The shrinkage of mitochondria during the onset of peroxidation matches changes observed in mitochondria of aging animals. Thioctacid (alpha-lipoic acid) prevents this initial shrinkage. However, its main effect in the system studied here is inhibition of active respiration.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Mitocôndrias Hepáticas
/
Peroxidação de Lipídeos
/
Ácido Tióctico
Limite:
Animals
Idioma:
En
Revista:
Mech Ageing Dev
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Alemanha