The discovery and initial optimisation of pyrrole-2-carboxamides as inhibitors of p38alpha MAP kinase.
Bioorg Med Chem Lett
; 20(13): 3936-40, 2010 Jul 01.
Article
em En
| MEDLINE
| ID: mdl-20570148
A novel pyrrole-2-carboxamide series of p38alpha inhibitors, discovered through the application of virtual screening, is presented. Following evaluation of activity, selectivity and developability properties of commercially available analogues, a synthesis program enabled rapid assessment of the series' suitability for further lead optimisation studies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pirróis
/
Proteínas Quinases p38 Ativadas por Mitógeno
/
Inibidores de Proteínas Quinases
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Descoberta de Drogas
/
Amidas
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2010
Tipo de documento:
Article