Intracellular trafficking of anandamide: new concepts for signaling.
Trends Biochem Sci
; 35(11): 601-8, 2010 Nov.
Article
em En
| MEDLINE
| ID: mdl-20570522
ABSTRACT
Endocannabinoids are key mediators of many aspects of human health and disease. The biological activity of anandamide, a prominent member of this group, depends on the metabolic control exerted by biosynthetic, catabolic and oxidative pathways working together. Cellular uptake and intracellular trafficking of anandamide are crucial steps in the process. Whereas the identity of anandamide transmembrane carriers remains undetermined, recent insights have been gained related to its intracellular stores (adiposomes) and intracellular binding proteins, particularly fatty acid binding proteins, albumin and heat shock protein 70. On this basis, we propose a reconsideration of the dogma that endocannabinoids are exclusively synthesized and released 'on demand', and suggest that their metabolic control is complemented by intracellular trafficking and storage in specific reservoirs.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Transdução de Sinais
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Ácidos Araquidônicos
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Espaço Intracelular
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Alcamidas Poli-Insaturadas
Limite:
Animals
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Humans
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2010
Tipo de documento:
Article
País de afiliação:
Itália